Cardarine gained popularity in the bodybuilding community in the mid-90s, and in 2006, the World Anti-Doping Agency (WADA) announced GW-501516 as a banned substance.
The substance was first found to be in the testosterone gel in 2005, but it was not considered "cheating" since any time a banned substance is present, it should be detected in the plasma, transparent labs bulk stack. WADA had no immediate plans on regulating the bodybuilding community using this substance.
The World Anti-Doping Agency then declared GW-501516 as an "Outlier" status of abuse, based on a review of the evidence on its use in bodybuilders, best bcaa ratio for building muscle, crazy bulk. However, there is no evidence that it can be used to enhance muscle size in bodybuilders. In fact, because of its toxicity, it would have been better to use anabolic steroids (i.e. testosterone enanthate) instead of the GW-501516 at the time of testing. So until WADA announces it is going to regulate use and use is regulated, bodybuilders will continue to use it, cardarine gw-501516.
For more information please review the following Wikipedia pages:
The testosterone "miracle"
Testosterone and bodybuilding
The testosterone molecule can undergo several processes in the testes:
Enanthate (T) – the main metabolite of testosterone
Gluconeogenesis (e.g. free) – the production of testosterone from gluconeogenesis in the testes
Transsulfuration – converting T to sulfated T
Enanthate sulfation – converts T sulfone to T
Enanthate hydrolase – which breaks down T
Enanthate dehydrogenase – which breaks down T sulfone to T
Transsulfuration of testosterone in the testes occurs in a two step process called transsulfuration:
Enanthate (T) sulfation (S)
Transsulfuration (T) hydrolase (H)
Enanthate sulfation (S) is followed by sulfative dehydrogenase (SDH) reaction. SDH is the second step of transsulfuration to convert T sulfone to T, best bcaa ratio for building muscle0.
The effect of SDH reaction is to convert T sulfone to T sulfate which is a more stable molecule than its parent T sulfone.
Sulfide (S and S²), is an unsaturated carbamate amino acid which contributes to the formation of the sulfated tredagon.
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